Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in various foods such as beets, spinach, and whole grains. It is a derivative of the amino acid glycine with three methyl groups attached to it. TMG plays a critical role in various biological processes, particularly in methylation and liver function.

   Supplemental Benefits of TMG:

Methylation: TMG is a methyl donor, meaning it provides methyl groups necessary for various biochemical reactions.

Homocysteine Conversion: Helps convert homocysteine, a potentially harmful amino acid, into methionine, which is beneficial for cardiovascular health.

Fat Metabolism: Aiding in the processing and breakdown of fats, preventing fatty liver disease.

Detoxification: Enhancing the liver’s ability to detoxify harmful substances.

Cellular Osmoregulation: TMG helps maintain cell volume and fluid balance, particularly in response to stress and dehydration.

Mood and Cognitive Function: Through its role in methylation, TMG may support neurotransmitter production, potentially improving mood and cognitive function.

   Forms and dosage:

Betaine Anhydrous: This is the most common and pure form of TMG, with no water molecules attached. It is highly concentrated and easily absorbed by the body. Often used in supplements aimed at enhancing athletic performance, liver function, and overall methylation support.

Betaine Hydrochloride (Betaine HCl): This form combines TMG with hydrochloric acid, making it acidic. It is primarily used to aid digestion by increasing stomach acid. Commonly found in digestive health supplements to support stomach acid production and improve nutrient absorption.

Betaine Citrate: TMG combined with citric acid. This form is less common but is sometimes used to improve the taste of the supplement or to combine the benefits of both betaine and citric acid. Used in some specialized formulations for liver support and overall health.

TMG (Trimethylglycine) “derived from natural betaine”, is essentially the same as Betaine Anhydrous. Both terms refer to the same compound and have the same chemical structure.   And if the supplement facts list only TMG, it is referring to Betaine Anhydrous.

   Daily dose: 500 – 3000 mg.