Nicotinamide Riboside (NR) is a form of vitamin B3 (niacin) and a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme found in all living cells. NAD+ is essential for energy production, DNA repair, and cellular communication, playing a pivotal role in maintaining cellular health and function.

   Supplemental Benefits of NR:

NAD+ Precursor: NR is converted into NAD+ through a series of enzymatic reactions. NAD+ is a key player in the mitochondrial electron transport chain, which produces ATP, the primary energy currency of the cell.

Mitochondrial Health: NR supplementation can enhance mitochondrial function by boosting NAD+ levels. Healthy mitochondria are essential for energy production and overall cellular health, reducing the risk of age-related diseases and conditions.

Sirtuin Activation: Sirtuins are a family of proteins involved in regulating cellular health and longevity. NAD+ is required for sirtuin activation, and NR, by increasing NAD+ levels, can enhance sirtuin activity. This has implications for aging, metabolism, and overall cellular resilience.

Cognitive Function: NR may support brain health and cognitive function by enhancing neuronal NAD+ levels. This can protect against neurodegenerative diseases and improve cognitive performance.

Immune Support: NR can support the immune system by enhancing cellular energy production and supporting the function of immune cells.

   Forms and dosage:

Nicotinamide Riboside Chloride (NRCl): This is the most common form of NR found in supplements. The chloride form is stable and ensures better absorption in the body.Often marketed under brand names like Niagen®, it is widely used in various NR supplements.

Nicotinamide Riboside Hydrogen Tartrate: This form is a salt of NR combined with hydrogen tartrate (tartaric acid). It is used to enhance the stability and shelf life of the NR compound. Less common than NR chloride, but still used in some dietary supplements for its stability properties.

Nicotinamide Riboside Hydrogen Malate: This form is a combination of NR and malic acid.   Malic acid is involved in the Krebs cycle, which can enhance cellular energy production.  The malate form is believed to facilitate better absorption and bioavailability.

Pure Nicotinamide Riboside (NR) is rarely found in supplement form without some form of stabilization agent. This is because NR is inherently unstable and can degrade easily, losing its effectiveness.  However, if you encounter a supplement labeled simply as “Nicotinamide Riboside” in the supplement facts without specifying a stabilizing agent, it might still include an unlisted form of stabilization to maintain its stability and effectiveness. Always check the ingredient list for any additional compounds that might be included for this purpose.

  Daily dose: 250 – 500 mg.