Alpha-lipoic acid (ALA) is a naturally occurring compound that plays a crucial role in cellular metabolism. It is both water- and fat-soluble, which allows it to work throughout the body. ALA is synthesized in small amounts by the human body, and it can also be obtained from various dietary sources and supplements. Its unique antioxidant properties have garnered significant attention in the fields of health and wellness.

   Supplemental Benefits of ALA:

Antioxidant Activity: ALA is a powerful antioxidant that helps neutralize harmful free radicals, protecting cells from oxidative stress. Unlike most antioxidants, which are either water- or fat-soluble, ALA can function in both environments, enhancing its protective effects.

Regeneration of Other Antioxidants: ALA aids in the regeneration of other important antioxidants, such as vitamin C, vitamin E, and glutathione. This ability to recycle antioxidants helps maintain a robust defense system against oxidative damage.

Metal Chelation: ALA has chelating properties, allowing it to bind to metal ions and facilitate their removal from the body. This function is particularly beneficial in detoxifying heavy metals like mercury, lead, and cadmium.

Cognitive Health: Due to its antioxidant and anti-inflammatory effects, ALA may support cognitive function and protect against neurodegenerative diseases like Alzheimer’s. Some studies suggest that ALA can help improve memory and reduce cognitive decline.

Peripheral Neuropathy:  Alpha-lipoic acid offers a promising approach to managing peripheral neuropathy, particularly for individuals with diabetic neuropathy. Its antioxidant, anti-inflammatory, and glucose-regulating properties make it a valuable supplement for reducing neuropathic pain and improving nerve function.

   Forms and dosage:

R-Alpha-Lipoic Acid (R-ALA): R-ALA is the naturally occurring form of alpha-lipoic acid, which is produced in small amounts by the body and found in foods. R-ALA is considered the most bioactive and bioavailable form, meaning it is more readily absorbed and utilized by the body compared to synthetic forms. It is more potent and effective at lower doses, making it a preferred choice for supplementation.

S-Alpha-Lipoic Acid (S-ALA): S-ALA is the synthetic form of alpha-lipoic acid. It is not naturally found in the body and is usually produced during the chemical synthesis of ALA. S-ALA is less bioavailable and less effective compared to R-ALA. It is generally less expensive but may require higher doses to achieve similar effects as R-ALA.

Alpha-Lipoic Acid (R,S-ALA): This form is a 50/50 mixture of R-ALA and S-ALA, also known as racemic ALA. Since it contains both forms, the overall bioavailability is lower than pure R-ALA but higher than pure S-ALA. It is the most common form found in supplements due to cost-effectiveness and availability.

Sodium R-Alpha-Lipoate (Na-R-ALA): Na-R-ALA is the sodium salt form of R-ALA, which enhances its stability and solubility. It has higher stability and better absorption compared to regular R-ALA, making it a highly effective form.

Potassium R-Alpha-Lipoate (K-R-ALA): K-R-ALA is the potassium salt form of R-ALA, offering similar benefits as Na-R-ALA. It has enhanced stability and bioavailability, similar to Na-R-ALA.

When the supplement facts label states just “alpha-lipoic acid” without specifying the form, it generally refers to the racemic mixture, which is a 50/50 blend of both R-Alpha-Lipoic Acid (R-ALA) and S-Alpha-Lipoic Acid (S-ALA).

   Daily dose: 300 – 600 mg.