Methylene Blue is a synthetic compound with a rich history of use in medicine, particularly as a dye, antiseptic, and therapeutic agent. It was first synthesized in the late 19th century and has since found applications in various medical fields due to its unique chemical properties. Methylene Blue (MB) is known for its deep blue color and has been used in medical diagnostics, as an antidote for certain poisonings, and in treating methemoglobinemia, a condition where hemoglobin is unable to carry oxygen effectively.

  Supplemental Benefits of Methylene Blue:

Mood Stabilization: Some studies suggest that MB may have antidepressant and anxiolytic effects, potentially through its action on mitochondrial function and neurotransmitter systems.

Reduction in Anxiety: MB might help reduce symptoms of anxiety by modulating brain energy metabolism and oxidative stress.

Enhanced Cellular Energy: By improving mitochondrial efficiency, MB can enhance overall cellular energy production, which may benefit various bodily functions.

Protection Against Mitochondrial Dysfunction: MB may protect against conditions associated with mitochondrial dysfunction, including chronic fatigue and metabolic disorders.

Reduction of Oxidative Stress: MB acts as a potent antioxidant by reducing oxidative stress and neutralizing free radicals.

  Forms and dosage:

Methylene blue can be purchased in liquid, tablet, capsule, powder, and topical forms. when purchasing methylene blue for supplementation or medical use, it’s advisable to choose   USP-grade (United States Pharmacopeia) products.    

 Liquid methylene blue at a concentration of 1% is a common formulation used for various applications, including laboratory research, medical uses, and as a dietary supplement.  A 1% solution means there are 1 gram of methylene blue in 100 mL of solution.  And in 1% methylene blue solution, 1 drop contains 0.5 mg of methylene blue. So, to achieve    5 mg. you would need 10 drops (10 x 0.5 mg).

Methylene blue powder can be dissolved in distilled water.  1gr. in 100ml.water(destiled/bottle)=1% solution.one drop = 0.5mg.  of methylene blue.

  Daily dose: 5 – 20 mg Begin with a lower dose to assess tolerance.   Blue tongue and green urine can occur with the use of methylene blue and are usually harmless side effects.